Download Adipose Tissue Biology by Christian Dani, Nathalie Billon (auth.), Michael E. Symonds PDF

By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)

This booklet is designed to supply a complete perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and progress, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental features of adiposity.

Show description

Read Online or Download Adipose Tissue Biology PDF

Best biology books

Glycomics: Methods and Protocols

As a result of the major contributions of carbohydrates to the practical range of the cellphone, the demanding research of the glycome has elevated past the learn of carbohydrate specialists and into the broader scope of the existence sciences. to help all scientists now delving into this important topic quarter, Glycomics: equipment and Protocols collects a compendium of particular laboratory protocols reflecting the expanding availability of pattern coaching, chromatographic, electrophoretic, mass spectrometric, and bioinformatic instruments in particular designed for the research of glycosylation.

Methods in Pharmacology: Molecular and Cellular Biology of Pharmacological Targets

The present quantity offers distinctive experimental protocols used to check plasma membrane ion channels as pharmacological ambitions. insurance comprises molecular and biochemical characterization of ion channels; fuctional research of ion channels after reconstitution, expression, or in cells; and particular tools and instruments.

Alzheimer’s Disease: Lessons from Cell Biology

Just like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their attractions mounted firmly at the ailment for a few years. Now, as this quantity amply demonstrates, finished researchers from different fields, who've idea deeply approximately phone organic difficulties are using their insights to Alzheimer's sickness.

Molecular Biology of B-Cell and T-Cell Development

Regardless of the large range of the cells of the hematopoietic approach, they're all derived from universal precursor cells which are generated within the fetus and persist into grownup existence. during this regard, Band T lymphocytes, which include the 2 palms of the antigen-specific and inducible immune method, even though functionally very diverse, are descendants of an analogous stem mobilephone precursor.

Extra info for Adipose Tissue Biology

Example text

2001). In contrast, mice lacking 11BHSD1 have reduced adiposity (Stewart and Tomlinson 2002). Moreover, obesity is associated with increased 11BHSD1 expression in adipose tissue in both rodents and humans (Rask et al. 2001). Locally produced cortisol may thus act in a paracrine manner to promote adipogenesis in visceral fat tissue. Several studies have reported the effects of MAPK family members on adipogenesis with conflicting results. ERK1 is required in the proliferative phase of differentiation, and blockade of ERK activity in 3T3-L1 cells or in mice inhibits adipogenesis.

Some drugs show a strong influence on adipogenesis. Highly active antiretroviral therapy on human immunodeficiency virus (HIV) infection, has been associated with metabolic syndrome including insulin resistance, dyslipidemia, peripheral lipoatrophy and visceral adiposity (Leow et al. 2003). Studies in cell culture have shown that several protease inhibitors, for example nelfinavir and indinavir, decrease preadipocyte differentiation and lipogenesis, while increasing apoptosis and lipolysis (Dowell et al.

The diminished proton gradient has to be restored by electron-driven proton pumping leading to oxygen consumption. Therefore, protons leaking through the membrane cause an “uncoupling” of oxygen consumption from ATP production (Fig. 2). Uncoupling (=proton leak) is a constant process in all mitochondria and accounts for more than 20% of total oxygen consumption in mammals (Rolfe and Brand 1996). Brown adipose tissue mitochondria are an exception to this rule. They are able to dissipate up to 100% of their proton motive force by a regulated leak mechanism driving nonshivering thermogenesis in this heater organ (Nicholls and Locke 1984).

Download PDF sample

Rated 4.85 of 5 – based on 27 votes