Download Aminoacyl-tRNA Synthetases in Biology and Medicine by Sunghoon Kim PDF

By Sunghoon Kim

This e-book will specialise in new molecular interactions and novel actions and the linked ailments which have been lately found from the stories of eukaryotic and mammalian aminoacyl-tRNA synthetases. moreover, the capability functions of ARS researches in biotechnology and medication should be addressed.

Show description

Read Online or Download Aminoacyl-tRNA Synthetases in Biology and Medicine PDF

Best biology books

Glycomics: Methods and Protocols

Because of the major contributions of carbohydrates to the practical variety of the telephone, the hard learn of the glycome has extended past the learn of carbohydrate specialists and into the broader scope of the existence sciences. to assist all scientists now delving into this important topic zone, Glycomics: equipment and Protocols collects a compendium of specified laboratory protocols reflecting the expanding availability of pattern instruction, chromatographic, electrophoretic, mass spectrometric, and bioinformatic instruments particularly designed for the research of glycosylation.

Methods in Pharmacology: Molecular and Cellular Biology of Pharmacological Targets

The present quantity offers certain experimental protocols used to review plasma membrane ion channels as pharmacological objectives. assurance comprises molecular and biochemical characterization of ion channels; fuctional research of ion channels after reconstitution, expression, or in cells; and particular equipment and instruments.

Alzheimer’s Disease: Lessons from Cell Biology

Just like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their points of interest fastened firmly at the illness for a few years. Now, as this quantity amply demonstrates, complete researchers from different fields, who've proposal deeply approximately phone organic difficulties are using their insights to Alzheimer's affliction.

Molecular Biology of B-Cell and T-Cell Development

Regardless of the large range of the cells of the hematopoietic process, they're all derived from universal precursor cells which are generated within the fetus and persist into grownup existence. during this regard, Band T lymphocytes, which include the 2 fingers of the antigen-specific and inducible immune procedure, even though functionally very varied, are descendants of an analogous stem cellphone precursor.

Extra resources for Aminoacyl-tRNA Synthetases in Biology and Medicine

Example text

Minajigi A, Francklyn CS (2008) RNA-assisted catalysis in a protein enzyme: the 20 -hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase. Proc Natl Acad Sci USA 105:17748–17753 64. Li L, Weinreb V, Francklyn C, Carter CW Jr (2011) Histidyl-tRNA synthetase urzymes: class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation. J Biol Chem 286:10387–10395 65. Pham Y, Kuhlman B, Butterfoss GL, Hu H, Weinreb V, Carter CW Jr (2010) TryptophanyltRNA synthetase urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementation.

Belrhali H, Yaremchuk A, Tukalo M, Berthet-Colominas C, Rasmussen B, Bosecke P, Diat O, Cusack S (1995) The structural basis for seryl-adenylate and Ap4A synthesis by seryl-tRNA synthetase. Structure 3:341–352 106. Berthet-Colominas C, Seignovert L, Hartlein M, Grotli M, Cusack S, Leberman R (1998) The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid.

Proc Natl Acad Sci USA 105:7428–7433 21. Rodriguez-Hernandez A, Bhaskaran H, Hadd A, Perona JJ (2010) Synthesis of Glu-tRNA (Gln) by engineered and natural aminoacyl-tRNA synthetases. Biochemistry 49:6727–6736 22. de Duve C (1988) Transfer RNAs: the second genetic code. Nature 333:117–118 23. Park SG, Schimmel P, Kim S (2008) Aminoacyl tRNA synthetases and their connections to disease. Proc Natl Acad Sci USA 105:11043–11049 24. Guo M, Yang XL, Schimmel P (2010) New functions of aminoacyl-tRNA synthetases beyond translation.

Download PDF sample

Rated 4.59 of 5 – based on 15 votes